Congress sex scandal history

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Author information (1)division of stem cell biology and developmental genetics, mrc nimr, the ridgeway, mill hill, london nw7 1aa, uk.   x chromosome inactivation is most commonly studied in the context of female mammalian development, where it performs an essential role in dosage compensation. However, another form of x-inactivation takes place in the male, during spermatogenesis, as germ cells enter meiosis. Meiotic sex chromosome inactivation (msci) is the process of transcriptional silencing of the x and y chromosomes that occurs during the meiotic phase of spermatogenesis. Meiotic sex chromosome inactivation (msci) is the early transcriptional silencing of the x and y chromosomes that occurs in the male germline meiotic phase 1-3. Msci has been observed in a vast range of taxonomic groups such as mammals, nematodes and grasshoppers 4-6. In mice, the organism where msci has been best characterized, cytological evidence shows that the x and y. What is meiotic sex chromosome inactivation? Meiotic sex chromosome inactivation, commonly referred to as msci, is an epigenetic silencing process that occurs exclusively in germ cells, the specialized cells that undergo meiosis, to form sperm and eggs. The mammalian x and y chromosomes share little homology and are largely unsynapsed during normal meiosis. This asynapsis triggers inactivation of x- and y-linked genes, or meiotic sex chromosome inactivation (msci). Meiotic sex chromosome inactivation protects unpaired sex chromosome dna from aberrant recombination and checkpoint surveillance machinery. Sex chromosomes undergo transcriptional silencing during late prophase due to the accumulation of conserved epigenetic changes. In mammalian spermatogenesis, the x and y chromosomes are transcriptionally silenced during the pachytene stage of meiotic prophase (meiotic sex chromosome inactivation, msci), forming a condensed chromatin domain termed the sex or xy body 1, 2, 3. During meiotic prophase in male mammals, the x and y chromosomes condense to form a macrochromatin body, termed the sex, or xy, body, within which x- and y-linked genes are transcriptionally repressed. Sex chromosomes, soon after their origination from autosomes, evolve such that the sex-related genes they harbor tend to be copied and moved to autosomes eventually over time 1, 2. Gene traffic the biased copying of sex-related genes from sex chromosomes onto autosomes is widely observed in mammals 1, 2 as well as other metazoans such as drosophila 3, 4, mosquitoes , stalk.

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